Job ID: 117464

PhD position in Neuroscience/Neuroendocrinology (ERC funded project)

Position: Ph.D. Student

Deadline: 1 May 2024

City: Bordeaux

Country: France

Institution: Inserm U1215, Neurocentre Magendie, University of Bordeaux.

Department:

Description:

We are seeking a highly motivated PhD student researcher to join the EnergyBalance and Obesity research team at the INSERM Unit U1215, Neurocentre Magendie in Bordeaux, France (https://neurocentre-magendie.fr).

Description: The overall aim of the Team is to elucidate the neurobiological mechanisms underlying the regulation of feeding and systemic metabolism. The Ghostbuster project will shed light on the molecular and functional heterogeneity of hypothalamic neuroendocrine neurons using state-of-the-art single-cell molecular and functional profiling methods. We will ‘hunt’ novel populations of ‘ghost’ neurons in the neuroendocrine hypothalamus that are characterised by high functional plasticity and atypical identity. A multidisciplinary approach will be used, combining lineage tracing strategies, nutritional interventions, single cell profiling of hypothalamic neurons, bioinformatic analysis and viral-based tools for targeting ghost neuron-related genes. These strategies will be combined with ex vivo patch clamp electrophysiology, behavioural, metabolic and hormonal assessments in mouse models of ghost neuron loss or gain of function under physiological or obesogenic conditions.

Requirements: highly motivated candidate and strongly interested in experimental neuroscience, neurophysiology, neuroendocrinology, hypothalamus, energy balance regulation, and obesity.

Starting Date and Term: September 2024, 3-years PhD contract fully funded through an ERC funded project.

Applications: Applications should be sent directly to Dr Carmelo Quarta (carmelo.quarta@inserm.fr) and should include a CV, a letter of motivation and contact details for at least one professional reference.