Job ID: 117625

postdoc position on non-coding RNA in traumatic brain injury

Position: Post-doctoral Position

Deadline: 31 March 2024

City: Ulm

Country: Germany

Institution: Ulm University

Department:

Description:

Open Postdoc position-Roselli lab in the Department of Neurology (Ulm University) on non-coding RNA in Traumatic Brain Injury

The postdoctoral position is funded by the German Science Foundation (DFG) in the context of the SFB1149 for 2.5 years (with potential for extension). Salary according to DFG rates. Starting date from March 1st, negotiable.

The project is entitled “Circular RNA in synaptic vulnerability and recovery after TBI” (performed in the context of the SFB1149 collaborative research center at Ulm University).  The aims of the project is to investigate the dynamics of synaptic circular RNA in trauma and to use overexpression/knockdown techniques to elucidate mechanistic links involving circular RNA and resilience of synaptic connectivity and neuronal integrity after mild traumatic brain injury.

The project involves in vitro and in vivo experiments and the experimental strategy is open to the input and preferences of the fellow. A broad range of techniques are involved in the project and their implementation is flexible depending on the strategy and preferences: intracerebral injection of viruses, TBI surgery, chemogenetics, behavioural assessment, quantitative confocal microscopy for in vivo experiments, array proteomics, transcriptomics, holographic live imaging, super-resolution microscopy, single-molecule RNA hybridization and laser microdissection-capture for in vitro experiments.

We look for candidates with a doctoral degree in the field of neurobiology or cell biology; we do not request prior experience in the indicated techniques or approaches (FELASA-B qualification in Germany is a plus) and we can provide training on all the listed approaches. The project goal is flexible and open to the contributions of the fellow.

The Systems Neurology laboratory, led by Francesco Roselli, at the Department of Neurology of Ulm University
(https://www.uniklinik-ulm.de/neurologie.html), involves about 20 members, between post-doc, graduate and master student level, from all over the world. The research inside the Systems Neurology lab receives funding from the German Science Foundation (multiple projects currently funded), the JPND program, the ERANET initiative, the Thierry Latran Foundation, the Radala/Frick Foundation, the Target ALS foundation and several industrial partners. In the last few years the Systems Neurology laboratory published papers in Nature Communications, Cell Reports, Journal of Neuroinflammation, Journal of Experimental Medicine, EMBO journal, Autophagy, Elife, and several others. More information about the Systems Neurology Laboratory can be found on the lab website: https://francescoroselli.wixsite.com/rosellilab