Job ID: 117735

Research Associate – UK Dementia Research Institute

Position: Post-doctoral Position

Deadline: 23 February 2024

City: London

Country: United Kingdom

Institution: Imperial College London

Department: Brain Sciences


Job summary

Applications are invited for a fully funded Cross-Centre Research Associate in Computational Genomics in the UK Dementia Research Institute. You will lead one or more projects characterising the epigenome of midbrain cell-types for the interpretation of Parkinson’s Disease susceptibility. You will be based at the Imperial College London under the immediate guidance of Dr Alexi Nott ( to profile the epigenome and chromatin architecture of midbrain cell-types with additional bioinformatics supervision from, and regular residential visits to Prof Caleb Webber’s team (Cardiff University) ( You will contribute to the design and analysis of large-scale ‘omics datasets with a primary focus on analysis of the epigenome and chromatin architecture to address major research questions relevant to PD.   The position is available initially for a period of 2 years, with potential for extension.

We are a globally leading multidisciplinary research institute of 800 staff investigating the spectrum of neurodegenerative disorders causing dementia, with laboratory-based research groups located at Imperial College London, University College London, the University of Cambridge, Cardiff University, Edinburgh University, and King’s College London.

Please contact Dr Alexi Nott for further discussion about the project and role.

This role is part of the UK Dementia Research Institute at Imperial College London, located in the Department of Brain Sciences. Postdocs in the UK DRI at Imperial enjoy excellent career development opportunities with:

  • Access to a range of cutting-edge technologies.
  • An inclusive and collegial working environment.
  • Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’.
  • Support from the Postdoc and Fellows Development Centre (PFDC) and Imperial and UK DRI ECR Communities.
  • The opportunity to mentor, supervise and teach students.

You will be a motivated and organised researcher, excited by the science we do.

Duties and responsibilities

    • Analysis and visualisation for large scale ‘omics datasets
    • Lead computational projects exploring the transcriptome, epigenome and 3D chromatin architecture of brain cell types
    • Work collaboratively as part of a multidisciplinary research team
    • Demonstrate an aptitude for an organised, methodical approach to your work

Essential requirements

    • Strong programming skills in R, Python, or other coding languages (e.g., C++, Matlab)
    • Experience within a High-Performance Computing environment
    • Research Associate: Hold a PhD (or equivalent) in Computational Biology, Mathematics or a closely related discipline, or equivalent research or industrial experience

Further information

The role is offered full time and fixed term, initially for two years with the potential for extension.

The post is based in the new UK DRI research labs on the White City Campus in West London. You will benefit from an active research (and social) environment in the Department of Brain Sciences, with additional research labs in the Burlington Danes Building on the nearby Hammersmith Campus.

Imperial is one of the UK’s most international universities and welcomes staff from all backgrounds and from all over the world.

Candidates without a PhD awarded will start on the Research Assistant pay scale.

Applicants are encouraged to contact Dr Alexi Nott ( for an informal discussion about the project and the role.

For more information about the UK DRI at Imperial, please visit:

For information about the Neuroepigenomics Lab, visit the Nott Group:

The UK Dementia Research Institute


About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are:

  • Respect
  • Collaboration
  • Excellence
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender reassignment, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

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