Job ID: 119046

PhD position to study neuro-immune interactions in chronic pain conditions

Position: Ph.D. Student

Deadline: 30 June 2024

Employment Start Date: 30 September 2024

Contract Length: 3+1 years

City: Lausanne

Country: Switzerland

Institution: Lausanne University Hospital (CHUV) and University of Lausanne (UniL)

Department: Anesthesiology (CHUV) / Department of Fundamental Neurosciences (DNF, UniL)

Description:

The laboratory of Dr. Marc R. Suter at the Lausanne University Hospital (CHUV, Switzerland) and Department of Fundamental Neuroscience (University of Lausanne) is seeking a highly motivated and enthusiastic PhD candidate to join our team.

The Suter lab is focused on understanding the neuro-immune mechanisms of chronic pain conditions. The lab investigates how bidirectional communication is taking place between neurons and the surrounding immune cells, both at the level of the peripheral (Dorsal Root Ganglion DRG) and central (Spinal cord) nervous system. We address questions which intend to better understand how this communication shapes cellular adaptations and how it contributes to the long-term establishment of a chronic pain phenotype. Our lab routinely uses various state-of-the-art approaches, including electrophysiology (patch-clamp and MEA recordings), viral transfection methods, molecular biology, fixed tissue immunofluorescent microscopy, optogenetic and animal behavior. We work in close collaboration with different clinicians and researcher from the Lemanic area to apply modern sequencing approaches on cell lines, ex vivo animal samples and patient’s samples. For more information about the Suter lab please visit: https://wwwfbm.unil.ch/dnf/group/understanding-the-mechanisms-contributing-to-neuropathic-pain.

The PhD candidate will be involved in a large translational project which aims to investigate the content and the functional effects of specific extracellular vesicles in this bidirectional neuro-immune communication.

Qualifications:
·     Master’s degree in neuroscience or related discipline.
·     The candidate must be able to work in a team frame. Additionally, he/she must demonstrate to be autonomous and independent.

  • Knowledge and strong interest in one or more of the following areas: molecular (e.g. single-cell RNA sequencing), synaptic (e.g. electrophysiology), behavioral (e.g. in vivo optogenetics/sensitivity testing).
  • Knowledge and interest in clinical research will be a plus.

Applications should include a detailed CV, a brief statement of research experience and interests (1-page max), and at least two references to Dr. Marc R. Suter (Marc.Suter@chuv.ch) and Dr. Paul Chu Sin Chung (Paul.ChuSinChung@unil.ch).