Job ID: 119331

PhD-project: Astrocyte-driven brain hyperexcitability as a novel treatment target for epilepsy

Position: Ph.D. Student

Deadline: 25 June 2024

Employment Start Date: 1 October 2024

Contract Length: 3 years

City: Oslo

Country: Norway

Institution: Oslo University Hospital

Department:

Description:

There is a striking lack of knowledge of the specific cellular mechanisms at play in epilepsy. For instance, the process transforming normal brain matter to a focus for epileptic seizures is elusive. Furthermore, key questions like “What cellular mechanisms set in motion or terminate an epileptic seizure?” and “How is brain excitability regulated” remain largely unanswered.

The aim of this project is to dissect mechanisms eliciting and curbing brain hyperexcitability, increasing our understanding of epilepsy and its relation to mechanisms involved in migraine. The project has the potential to leverage novel treatment concepts for these conditions.

Representative articles illustrating the topic and type of experimental work and analyses we perform can be found in some of our recent papers:

Enger and Heuser 2024, Front Netw Physiol
Bojarskaite et al. 2023, Nature Communications
Heuser et al. 2018 Cereb Cortex

Applications must be submitted via this link.