Job ID: 119592

Postdoctoral researcher Fellow to study the function of Wnt-Frizzled signalling in synaptic connectivity in th mammalian brain

Position: Post-doctoral Position

Deadline: 28 July 2024

Employment Start Date: 16 September 2024

Contract Length: one year in the first instance but it can be extended to three years

City: London

Country: UK

Institution: University College London (UCL)

Department: Cell and Developmental Biology

Description:

Applications are invited to apply for a postdoctoral scientist position to work on a project aimed at elucidating the function of Wnt-Frizzled signalling in synaptic connectivity. This project will be conducted in the laboratory of Professor Patricia Salinas at UCL. The project focuses on the unravelling the mechanisms that control the levels of Wnt receptors in neurons and at synapses, a process that is crucial for the formation of neuronal connections. The project is based on our recent results published in Developmental Cell (Teo et al., 2023, Developmental Cell 58, 2063–2079). The postdoctoral researcher will use a range of state-of-the-art cell biology and imaging techniques, gene editing in neurons to understand how Wnt receptors are modified to promote synaptic connectivity. The postdoctoral fellow will also use optogenetic approaches to study synaptic connectivity.

Applications are particularly welcome from candidates with research expertise in one of the following areas: cell imaging, post-translational modifications and cellular neurobiology and synaptic connectivity. Experience in cell imagining techniques would be very advantageous.

The position is available with an immediate start. The starting salary is on UCL grade 7 in a range of £ 42,099- £50,585 including London Allowance. Funding is available for up to three years with one year in the first instance.

Informal enquiries should be addressed to Professor Patricia Salinas (email: p.salinas@ucl.ac.uk). For an outline of the lab’s research interests see: https://salinaslabucl.co.uk/