Job ID: 12512

Post-doctoral position in Mainz/Germany

Position: Post-doctoral Position

Deadline: 1 October 2021

City: Mainz

Country: Germany

Institution: University Medical Center, Johannes-Gutenberg-University Mainz

Department: Institute of Physiology, FTN

Description:

Development of advanced promoter elements for future gene therapy vectors

A position for a post-doctoral fellow in the laboratory of Simon Rumpel, University Medical Center of the Johannes Gutenberg University Mainz, Germany is available. It is part of a collaborative research project conducted jointly with the Institute of Molecular Biology (IMB) in Mainz and a partner from industry.

Vector technology for therapeutic applications is rapidly gaining importance. A core element of any vector is the promoter controlling the expression of the gene of interest. Future promoter elements will be selected upon their ability to drive gene expression at therapeutic levels in specific target cells.

The aim of this project is to identify genomic control elements suitable for the design of small, powerful artificial promoters in the context of Adeno-associated viruses (AAV). Towards this end, we recently established efficient methodology allowing to identify genomic sequences in vivo model systems, including the mouse brain. This project relies on the tight interaction between scientists with experimental and bioinformatics background.

Applicants have obtained a PhD in Molecular Biology or related field, have excellent communication skills and have an interest to work in a collaborative and international environment. Profound knowledge in advanced molecular biology and cloning is essential. Additional experience in AAV biology and vector production is preferred. This position offers an exciting career opportunity at the interface of basic and applied research.

For further information, or to apply, please contact Simon Rumpel (sirumpel@uni-mainz.de). Applications (single PDF) should include a motivation letter, the applicant’s CV, list of publications and contact information for two references.

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