Job ID: 58594
Research Associate in Cellular and Molecular Neuroscience
Position: Post-doctoral Position
Deadline: 6 September 2021
Employment Start Date: 15 October 2021
Contract Length: 3 Years
Country: United Kingdom
Institution: Imperial College London
Department: Brain Sciences
A Research Associate position is available in the Laboratory of Translational Neuroscience of Imperial College London, starting from October 2021.
The aim of this exciting project titled ‘A single-cell transcriptomic map of the human developing cortex in Down syndrome’ is to gain new and fundamental insights into how the generation of cells and circuitry of the human neocortex are perturbed in Down syndrome (DS). My team recently discovered reduced synchronized excitatory network activity in the immature DS cortex, which could contribute to the progression of cognitive symptoms (Real, Peter, Trabalza et al Science 2018). The overall goal of this project is to capture the mechanisms of cortical circuit dysfunction in DS. We will achieve this by revealing the molecular and cell type-specific landscape of the DS cortex from both human post-mortem fetal brain samples and induced pluripotent stem cell (iPSC)-derived cortical tissue grafts by single-nucleus RNA sequencing (in collaboration with Dr Boaz Levi of the Allen Institute for Brain Sciences in Seattle). This atlas of human neocortical cell types, their relative proportions and the differentially regulated genes will constitute an important resource for the scientific community that will be made publicly available.
For more information visit our Imperial College London and personal www.DePaolaLab.com web pages.