Job ID: 58772

In vivo electrophysiology and dynamic imaging to study the circuit mechanisms underlying the neural coding of time

Position: Post-doctoral Position

Deadline: 1 October 2021

Employment Start Date: 1 November 2021

Contract Length: 2 years, renewable

City: Paris

Country: France

Institution: Pasteur Institute

Department: Laboratory of Synapse and Circuit Dynamics, Department of Neuroscience

Description:

The Synapse and Circuit Dynamics laboratory at the Institut Pasteur is seeking neurophysiologists interested in a systems-level understanding the synaptic and dendritic mechanisms of temporal coding of multisensory information within brain circuits, particularly within the cerebellum. We are particularly interested in the sensory-motor transformation necessary to drive motor and cognitive actions. Multiple projects are available that will examine, in awake behaving animals, how neural circuits can leverage short-term synaptic dynamics to encode time within neural circuits or how electrical synapses between interneurons contribute to coding temporal features of neural activity to drive precisely timed behaviors. The successful candidate will benefit from working in a multidisciplinary team with in situ and in vivo neurophysiologists, physicists (optics), and theoretical neuroscientists working in a highly collaborative environment. Hypotheses will be tested using high-speed random access two-photon imaging of genetically encoded calcium and glutamate sensors to monitor neural and synaptic population dynamics during head-fixed timing behaviors. Imaging approaches will be complimented by high-density single-unit recordings using Neuropixels.  Thus, candidates should have previous experience in electrophysiology, dynamic imaging, or head-fixed behaviors, and should have a good command of signal analysis.