Job ID: 58779

Synaptic and dendritic mechanisms underlying neural circuit dynamics that drive behavior

Position: Ph.D. Student

Deadline: 1 December 2021

Employment Start Date: 1 October 2021

Contract Length: 3 years

City: Paris

Country: France

Institution: Pasteur Institute

Department: Laboratory of Synapse and Circuit Dynamics, Department of Neuroscience

Description:

The Synapse and Circuit Dynamics laboratory at the Institut Pasteur is seeking a Ph.D. candidate interested in a cellular or systems-level understanding of the synaptic and dendritic mechanisms underlying temporal coding of multisensory information within brain circuits, particularly within the cerebellum. The laboratory is interested in the sensory-motor transformation necessary to drive motor and cognitive actions. Multiple projects are aimed at understanding how the brain encodes time at different mechanistic levels: 1) the dynamic synaptic and neuronal mechanisms in brain slices, and 2) the circuit mechanism necessary to encode temporal patterns of neural activity to drive precisely timed behaviors. The successful candidate will benefit from working in a multidisciplinary team with in situ and in vivo neurophysiologists, physicists (optics), and theoretical neuroscientists working in a highly collaborative environment. Hypotheses will be tested using patch-clamp electrophysiology, two-photon imaging, and super-resolution (STED) imaging at the subcellular scale. At the systems level, the candidate will use high-speed random access two-photon imaging of genetically encoded calcium and glutamate sensors to monitor neural and synaptic population dynamics during head-fixed timing behaviors. Imaging approaches can be complemented by high-density single-unit recordings using Neuropixels.  Thus, candidates should have some previous experience in either electrophysiology, dynamic imaging, or head-fixed behaviors and should have some experience with signal analysis. Please send a CV and a letter of motivation highlighting your qualifications and specific interests in the project and laboratory to David DiGregorio (david.digregorio@pasteur.fr).