Job ID: 59134

Post-doctoral position in the field of Stem Cell Biology

Position: Post-doctoral Position

Deadline: 31 December 2021

Employment Start Date: 1 September 2021

City: Québec

Country: Canada

Institution: Université Laval



Highly motivated candidates are invited to lead several new projects to address fundamental questions on neuronal differentiation, migration and maturation, in particular with regard to inhibitory neurons, related to the neurodevelopmental component of major psychiatric diseases including schizophrenia, bipolar disorders and major depression disorder. Experimental approaches, including biochemistry, genetics, cell biology, live cell imaging and electrophysiology are employed on iPSC-derived neurons coming from unique high-risk cohorts composed of both patients suffering from major psychoses and their high-risk offspring.

Thus, the project is part of a highly competitive research endeavor, and offers excellent perspectives for scientific career development. We offer a great team spirit within a interdisciplinary  environment , state-of-the-art equipment and work technology (new cutting-edge multimodal live cell imaging, a large library of recombinant AAV vectors expressing fluorescent sensors, availability of core units for proteomics and transcriptomics, etc.).

Under the supervision of the principal researcher, the candidate will have to perform the following tasks, among others, with the help of laboratory technicians:

  • Developing and optimizing protocols for the neural differentiation of human iPSCs.
  • Design and perform experiments on human iPSC-derived neuronal cells with different techniques including ICC, FACS, qPCR, wester blot, single cell analysis, as well as multimodal super-resolution live cell imaging developed in the Laboratory.
  • Write and review of scientific articles
  • To maintain knowledge of current developments in the field of research notably by attending international congresses and workshops

The ideal candidate would have a Ph.D. in neurobiology, developmental neuroscience, stem cell biology or related fields. Additionally, the successful candidate will have proven solid experiences with iPSC-derived cell culture, ideally has already differentiated such cell lines into neurons, and is also experienced with, immunocytochemistry and molecular biology. Knowledge in the field of live cell imaging and/or electrophysiology is an asset.