Job ID: 59745
PhD position in brain senescence and Alzheimer’s disease
Position: Ph.D. Student
Deadline: 1 October 2021
Employment Start Date: 18 October 2021
Institution: Université catholique de Louvain (UCLouvain)
Department: Institute of Neuroscience (IoNS) - Cellular and molecular division (CEMO)
We are looking for an enthusiastic young scientist to work on a project that aims at unravelling how the senescence process triggers brain dysfunction and neurodegenerative pathologies, with a particular focus on Alzheimer’s disease (AD). It has been recently suggested that senescent cells might contribute to brain dysfunction in the aging brain, and a correlation between telomere attrition and AD has been proposed. The first aim of the project is to deeply characterize brain senescence in a mouse model of accelerated aging (Terc-/-), which is deficient for telomerase activity and thus exhibits important telomere attrition after 3 generations. Additionally, the candidate will study how pathological aging creates a context favouring the onset and progression of AD lesions by crossing Terc-/- mice with a tauopathy mouse model (MAPTP301SPS19), which recapitulates the neuropathological features observed in several neurodegenerative diseases, the most prevalent being AD. The project requires handling the transgenic mice and obtaining mouse samples from adult brain tissue and neuronal primary cultures. Primary used techniques will include histological imaging, western blot, RT-qPCR, and proteomics.
Candidates are expected to have a strong background in molecular and cellular biology with a good knowledge of neurosciences and neurodegenerative disorders. Basic experience with conventional molecular biology techniques is desirable. A certificate of competence in animal experimentation would be an asset, as well as previous experience in the experimental manipulation of mice.
The project will be conducted under the supervision of Dr. Nuria Suelves Caballol and Prof. Pascal Kienlen-Campard (UCLouvain, Institute of Neuroscience). Good English communication skills are required. A PhD grant is available for 1 year with possible extension. The net monthly amount of the scholarship is calculated according to university standards.