Job ID: 60962
Post-doctoral position: Developing a new therapeutic device to detect and treat pathology in the brain
Position: Post-doctoral Position
Deadline: 30 November 2021
Employment Start Date: 3 January 2022
Contract Length: 3 years
Institution: Fonds de dotation Clinatec
We are looking for one post-doctoral candidate to join our team at Fonds de dotation Clinatec, Centre de recherche biomédicale Ed. J. Safra, Grenoble, France. This department tests medical devices for biocompatibility and is involved in the design, development and validation of innovative diagnostic and treatment approaches.
Topic of the study :
This series of experiments will focus on the development of a helmet-like device that can both detect and treat pathology in underlying brain tissue. Such a device will be of immense therapeutic value in the treatment and prevention of major neurological disorders, such as Alzheimer’s disease, epilepsy and depression. We plan to develop a device based on broadband near-infrared spectroscopy (NIRS) that will measure, non-invasively, in-vivo changes in mitochondrial function across the brain surface; the reflection of the applied near-infrared light will monitor changes in the oxidation of cytochrome c oxidase in complex IV of the mitochondrial electron transport chain, as well as changes in oxygenated and deoxygenated haemoglobin. The new device will also include the ability to apply photobiomodulation (eg, 670nm red light or longer), which has been shown to improve mitochondrial pathology and function across many cells of the body, including those in the brain and other parts of the nervous system.
The Clinatec facility has access to world-class optical and laser engineering departments within CEA-Leti, which is specialised in the further development of biomedical devices to improve the health and well-being of the community. The successful candidate will liaise with individuals in these departments and be involved in the design and development of the new light device. In order to test the validity and efficacy of the emerging device, the candidate will undertake routine behavioural tests and immunohistochemical analysis in a range of animal models of disease, for example Alzheimer’s disease, epilepsy and depression.
The applicants should have experience in the development and use of biomedical devices, preferably optical and laser, as well as near-infrared spectroscopy. Some experience in animal behavioural testing and immunohistochemistry would be an advantage.
Applicants must have a PhD in biomedical engineering or neuroscience. Good written and verbal English communication skills are required and French practice would be appreciated. Preference will be given to candidates with an excellent track record of peer-reviewed publications.
The candidate will have the opportunity to have an attractive 3-year post-doc grant.