Job ID: 63289

Intracellular mechanisms within Oligodendrocytes in Health and Disease

Position: Ph.D. Student

Deadline: 10 December 2021

Employment Start Date: 1 July 2022

Contract Length: 3 years

City: Erlangen

Country: Germany

Institution: Friedrich-Alexander Universität Erlangen-Nürnberg

Department: Department of Molecular Neurology

Description:

A PhD position is available in the laboratory of Prof. Dr. Jürgen Winkler and Prof. Dr. Friederike Zunke working on “Oligodendrocyte function and metabolism in health and disease” at the Department of Molecular Neurology at the Universitätsklinikum Erlangen/ Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany.

The aim of our work is the identification and characterization of intracellular mechanism and risk factors underlying neurodegenerative disorders and rare neurological diseases. Our research focus is on oligodendrocyte homeostasis, function and maturation, since this cell type is essential for proper neuronal functioning. The main focus of this project will be on intracellular mechanisms, implying protein synthesis, trafficking as well as degradation pathways. Our overall ambition is to improve the understanding of these intracellular mechanisms in different cell types within the CNS in health and disease. This will not only help to understand disease pathways, but also enables us to translate our knowledge in order to help identifying novel interventional target as well as markers for early disease diagnosis.

The doctoral student will be integrated into the DFG-funded Research Training Group 2162 (GRK2162) “Neurodevelopment and CNS Vulnerability”. The GRK2162 offers:

  • a 3-year structured PhD program with interdisciplinary thesis research,
  • a vibrant, collaborative scientific environment,
  • supervision and mentorship by a team of internationally renowned experts,
  • State-of-the-art research facilities and
  • advanced training opportunities (scientific, skills, career) in English.

Who we look for:

  • highly motivated and curious applicants that want to connect basic research with translational perspectives in an encouraging international and interdisciplinary scientific environment
  • candidates should have a strong interest in cell biology, protein function, and intracellular mechanisms
  • experiences with protein biochemistry, cell culture, and/or mouse models is advantageous but not mandatory
  • a team player, willing to answer urgent research questions in a collaborative research environment

 

How to apply:

Please submit applications via email as a single file to grk2162@fau.de

(1) Letter of motivation

(2) Curriculum vitae

(3) Transcript of Records

(4) Summary of Research Experience and Master Project

(5) List of publications

(6) Two letters of reference

 

For further information on the scientific project please contact:

Prof. Dr. Jürgen Winkler

juergen.winkler@uk-erlangen.de

Prof. Dr. Friederike Zunke,

friederike.zunke@fau.de

Department of Molecular Neurology

University Hospital Erlangen/Friedrich-Alexander-University (FAU)