Job ID: 111348
PhD position in neuroscience in Bordeaux
Position: Ph.D. Student
Deadline: 1 September 2023
Employment Start Date: 1 October 2023
Contract Length: 3 years
City: Bordeaux
Country: France
Institution: University of Bordeaux
Department: Interdisciplinary Institute for Neuroscience
Description:
Structural remodeling of hypothalamic circuits by microglia in obesity
Keywords: STED imaging, Neuronal plasticity, Microglia, Electrophysiology, Obesity, Hypothalamus
Co-Supervisors: Valentin Nägerl (valentin.nagerl@u-bordeaux.fr) / Agnès Nadjar (agnes.nadjar@u-bordeaux.fr)
The PhD project aims to unravel the physical and molecular interactions between microglia and neurons in the hypothalamus in a mouse model of obesity, where it has been shown that an obesogenic diet induces microglial neuroinflammation and major changes in the functional neuroanatomy of the hypothalamus. We will use a combination of super-resolution microscopy and opto/electrophysiological approaches to study in living brain slices alterations in microglia-neuron interactions brought on by an obesogenic diet.