Job ID: 116859
Molecular Mechanisms of Neuronal Cell function and Disease using 2D and 3D Stem Cell-Based Models of Human Brain
Position: Post-doctoral Position
Deadline: 23 November 2023
Employment Start Date: 1 February 2024
Contract Length: 1 year renewable
City: Genoa
Country: Italy
Institution: University of Genova
Department: Department of Experimental Medicine
Description:
Our Neurophysiology Lab is dedicated to unraveling the intricate mechanisms underlying neural cell functioning at the cellular and molecular levels. To address these issues, we have recently expanded our research lines to include the development of human brain models.
The research group is experiencing rapid growth, thanks to PNNR MNESYS funding and is in collaboration with Center of Synaptic Neuroscience of Italian Institute of Technology directed by Prof. Fabio Benfenati, with dynamic scientific environment and access to state-of-the art facilities.
The position, financed by PNNR MNESYS, has the primary objective to establish advanced human 2D and 3D stem cell-based brain models that will serve as powerful tools for studying neurological disorders with particular attention to neurodevelopmental and neuropsychiatric diseases. Functional imaging, electrophysiology, and omics techniques will be combined, enabling the study of disease specific mechanisms and the unique processes relevant to neurological disorders.
By joining our team, you will have the opportunity to contribute to cutting-edge research in developing 2D and 3D stem cell-based models of the human brain and to groundbreaking research, that has the potential to make a significant impact for elucidating the molecular basis of neurological disorders and advancing research into new therapies.
Why Apply?
- Contribute to groundbreaking research in the field of neurological disorders with great translational value thanks to collaboration with Geneticists and Clinicians.
- Collaborate with distinguished Researchers and leverage your expertise in neurophysiology, molecular mechanisms of neurotransmitter release and synapse regulation, among others.
- Gain invaluable experience in the generation and implementation of advanced 2D and 3D models of brain development.
- Supervise and mentor talented students pursuing their PhD and MSc degrees.
- Present research findings at prestigious International Conferences and contribute to high-impact scientific publications.
Responsibilities:
- Setting mouse primary neuronal cultures and neuronal phenotypic characterization by morphological, biochemical and live cell imaging approaches.
- Cultivate and maintain induced pluripotent and embryonic stem cells (iPSC/ESC).
- Develop and implement advanced 2D and 3D models of brain development (Hippocampal and Ganglionic Eminence organoids, Assembloids), for genetic epilepsies and neuropsychiatric disease modeling.
- Prepare comprehensive reports and contribute to impactful research articles.
- Deliver compelling presentations and actively participate in esteemed international conferences.
Qualifications:
- Expertise in molecular and cellular biology
- Previous experience in live Imaging and Biochemistry are welcome.
- Impeccable work ethics and exceptional organizational skills.
Additional Qualifications:
- Proficiency in utilizing CRISPR/Cas9 genome editing technologies or CRISPR screening.
- Expertise in stem cell biology, particularly iPSC/ESC, and the ability to develop in vitro differentiation models toward neuronal identity (2D or 3D).
- Proficiency in employing high-throughput genomic techniques (e.g., sc-RNA seq etc).
Terms of employment:
- Application deadline 23 November 2023.
- Starting date 1 February 2024.
- 2 years position
- Salary will be commensurate to experience.
Contact:
Interested candidates are requested to submit their detailed curriculum vitae and any relevant inquiries to:
Prof. Anna Corradi: acorradi@unige.it (orcid http://orcid.org/0000-0002-3449-9167 )
Dr. Bruno Sterlini bruno.sterlini@unige.it (orcid: https://orcid.org/0000-0001-8247-4709).
Prof. Anna Fassio: anna.fassio@unige.it (orcid http://orcid.org/0000-0002-8801-038X).