Job ID: 117108
Two Postdoctoral Research Associate positions studying ER-mitochondria signaling in Alzheimer’s disease and related dementias
Position: Post-doctoral Position
Deadline: 8 January 2024
Employment Start Date: 1 February 2024
Contract Length: 3 years and minimum 1.5 years
City: London
Country: United Kingdom
Institution: KIng's College London
Department: Department of Basic and Clinical Neuroscience
Description:
King’s College London. Two Postdoctoral Research Associate positions to study the role of defective endoplasmic reticulum (ER)-mitochondria signaling in Alzheimer’s disease and related dementias
Applications are invited for 2 postdoctoral research associates to study defective ER-mitochondria signaling in Alzheimer’s disease and related dementias. Both positions will be based in the Department of Basic and Clinical Neuroscience at King’s College London.
ER-mitochondria signaling and its role in dementia are highly topical areas of research and the grant holders have made major contributions to these fields. The successful applicants will join a multi-disciplinary group that seeks to understand the mechanisms by which ER-mitochondria signaling is perturbed in dementia and how correcting damaged ER-mitochondria signaling might be therapeutic for Alzheimer’s disease and related dementias.
One post is funded by Alzheimer’s Research UK until 31 december 2025. The project will use cell, molecular and advanced microscopy approaches to investigate the therapeutic potential of targeting ER-mitochondria tethering proteins as a treatment for dementia. The work will focus on novel compounds that we have identified from prior drug screens and will involve collaborations with major Pharmaceutical companies.
The second post is funded by the UK Medical Research Council and is for 3 years. The work will again use cell, molecular and advanced microscopy approaches including analyses of novel transgenic mice we have created to investigate the mechanisms by which damage to ER-mitochondria signaling occurs in dementia.
Experience in cell and molecular biology approaches including advanced light microscopy and experimental manipulation of neurons would be advantageous for both posts. Knowledge of defective signaling processes in dementia and related disorders will also be useful. The successful applicants will join an established research group based on the Denmark Hill campus and will have access to state-of-the-art facilities in both King’s College and the King’s College Dementia Research Institute. For further information on our work see:
https://kclpure.kcl.ac.uk/portal/en/persons/chris.miller
The deadline for applications are 8th january 2024 and salaries are on the scale £42405-£49785 including London weighting. For further information and to apply for these posts go to:
Post 1 (ARUK funded) https://www.kcl.ac.uk/jobs/078665-research-associate-er-mitochondria-signaling-as-a-therapeutic-target-for-dementia
Post 2 (MRC funded) https://www.kcl.ac.uk/jobs/077865-research-associate-er-mitochondria-signaling-in-dementia-in-the-department-of-basic-and-clinical-neuroscience