Job ID: 117380

Post-doc Understanding and targeting CHEMOtherapy-related neuroTOXicity (CHEMOTOX)

Position: Post-doctoral Position

Deadline: 22 January 2024

Employment Start Date: 1 April 2024

Contract Length: one year

City: Torino

Country: Italy

Institution: University of Torino

Department: Neuroscience

Description:

Cancer patients life expectancy is substantially increased. CNS neurotoxicity, defined as chemotherapy-induced cognitive impairment (CICI) is frequent, impairing memory, learning, etc during and after discontinuation of chemotherapy. Chemotherapy-induced PNS toxicity (CIPN) ranks among the commonest dose-limiting toxicities of several widely used anticancer drugs. The cellular and molecular events underlying CICI and CIPN pathogenesis still remain elusive. This project is based on 3 main pillars: 1: CICI and CIPN can be reliably modeled in new preclinical models based on schedules that are more close to the clinical use 2: CICI and CIPN may have detectable morphological and functional correlates 3: CICI and CIPN can be simultaneously modulated by the administration of histone deacetylase inhibitors.
Suggested skills: experience in animal experimentation, histology, immunocytochemistry, molecular analysis and confocal microscopy

The call is open: https://pica.cineca.it/unito/assegni-di-ricerca-unito-2023-iv-medto
DEADLINE: January 22nd, 2024 1:00 pm CET