Job ID: 118147
The role of circadian clock in the antidepressant mechanism of acute sleep deprivation
Position: Ph.D. Student
Deadline: 10 May 2024
Employment Start Date: 1 October 2024
Contract Length: 3 years
City: Strasbourg
Country: France
Institution: Institute for Cellular and Integrative Neurosciences
Department:
Description:
We are looking to hire a motivated PhD student in our laboratory to work on project investigating the crosstalk between the circadian clock and homeostatic plasticity in mood disorders, focusing on the role of clock in the antidepressant mechanism of sleep deprivation.
Our research is focused on the cellular and molecular mechanisms mediating the rapid antidepressant effects of sleep deprivatiaon and ketamine (Serchov et al., Neuron, 2015) and the role of adenosinergic and glutamatergic signalling (Holz et al., Neuron, 2019). Our current interests are the involvement of molecular circadian clock in antidepressant treatments.
To tackle these important questions, we use a combination of in vivo electrophysiology (EEG/LFP), in vivo fiber photometry, molecular biology methods and complex behavioural analyses.
The successful candidate must have MSc in life science (Neuroscience/Biology/Medicine or related field) within TOP10-20% ranking, excellent English communication skills and previous EU/France recognized certified experience with stereotactic surgeries in rodents (virus injections, canula/electrode implantation. Expertise in behavioral paradigms, fiber photometry, EEG/LFP recordings and analyses, MathLab (or similar) is an important advantage.
Our laboratory belongs to the Institute for Cellular and Integrative Neurosciences, in Strasbourg, France. It is an international team closelly collaborating with the Sleep Research Center (CIRCSom) at University Hospital Strasburg and the Psychiatry Uniklink Freiburg in Germany.
Interested applicants should send their applications as a single PDF file including CV, MSc certificate with grades and ranking, motivation letter (half page), relevant other certificates and contact information of 2 referees.