Job ID: 118291

Role of circadian clock in the antidepressant mechanism of sleep deprivation

Position: Ph.D. Student

Deadline: 12 May 2024

Employment Start Date: 1 October 2024

Contract Length: 3 years

City: Strasbourg

Country: France

Institution: Institute of Cellular and Integrative Neuroscience (INCI), CNRS UPR3212, University of Strasbourg

Department:

Description:

We are looking to hire a motivated PhD  candidate in our laboratory to work on  project investigating the crosstalk between the circadian clock and homeostatic plasticity in mood disorders.

Our research is focused on the cellular and molecular mechanisms mediating the rapid antidepressant effects of sleep deprivatiaon and ketamine (Serchov et al., Neuron, 2015) and the role of adenosinergic and glutamatergic signalling (Holz et al., Neuron, 2019). Our current interests are the involvement of molecular circadian clock in mood disorders and antidepressant treatmnets.

Activities: To tackle these important questions, we use a combination of in vivo electrophysiology (EEG/LFP), calcium imaging (fiber photometry), molecular biology methods and complex behavioural analyses.

Compétences (skills): The successful candidate must have MSc in life science (Biology, Neuroscience or equivalent) with excellent marks and TOP 10-20% ranking, good English communication skills.  Previous EU/France recognised certified experience with stereotactic surgeries in rodents (virus injections, canula/electrode implantation and expertise in behavioural paradigms, fiber photometry, EEG/LFP recordings and analyses, MathLab (or similar) is an important advantage.

Contexte (work context): Our laboratory belongs to the Institute for Cellular and Integrative Neurosciences, in Strasbourg, France. It is an international team closelly collaborating with the Sleep Research Center (CIRCSom) at University Hospital Strasburg and the Psychiatry Uniklink Freiburg in Germany.

Interested applicants should send their applications as a single PDF file including CV, motivation letter (half page), relevant certificates and contact information of 2 referees to serchov@inci-cnrs.unistra.fr