Job ID: 120184

Postdoc in imaging of synaptic function at Department of Neuroscience

Position: Post-doctoral Position

Deadline: 20 September 2024

Employment Start Date: 1 December 2024

Contract Length: 2 years

City: Copenhagen

Country: Denmark

Institution: University of Copenhagen

Department: Department of Neuroscience

Description:

We are looking for a highly motivated and dynamic researcher for a 2-year position to start at December 1st 2024, or after agreement.

The project includes the study of cellular models of neurodevelopmental delay and epilepsy using live cell imaging of neuronal activity. The purpose is to detect consequences of disease mutation on the circuit level using imaging methods, which will be amenable to drug discovery.

Information on our research group can be found: https://in.ku.dk/research/sorensen-lab/

Our research

Our research group is interested in the mechanism of neurotransmitter release in chemical synapses, and the molecular basis for neurodevelopmental diseases and epilepsy (see Verhage and Sørensen, 2020, Neuron 107:22-37). We study these properties using an interdisciplinary approach, which includes human induced pluripotent stem cell (hIPSC)-derived neurons or mouse neurons, combined with microscopy, electrophysiology, and more lately omics methods. Our group is international and based on teamwork and interdisciplinarity. We collaborate with clinicians and patient groups. Our group is inclusive and fosters a collaborative and supportive spirit.

Your job

We have developed several different murine and human models of neurodevelopmental disease, based on mutation in the neurotransmitter release machinery (e.g. Kádková et al., 2024, Elife 13:RP886197). We now want to investigate how these mutations give rise to aberrant circuit activity underlying epilepsy and neurodevelopmental delays. Your task will be to use live cell microscopy of in vitro neuronal populations with fluorescent reporters, perform image analysis, and identify imaging parameters that are changed by mutation.

Qualifications:

We are looking for a highly motivated and enthusiastic scientist with a high potential for original research. The following competencies and experiences are required/optional:

Essential experience and skills:

  • PhD or equivalent degree in natural or medical science.
  • You have an excellent scientific track record.
  • You have solid experience with cell culture methods.
  • You have experience in fluorescence microscopy.
  • You are enthusiastic, highly motivated and a self-starter.
  • Proficient communication skills and ability to work in teams.
  • Excellent English skills written and spoken.

 

Desirable experience and skills

  • Experience with human stem cell work and/or live cell microscopy.

 

Place of employment

The place of employment is at the Department of Neuroscience, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories within the Mærsk Tower.

 

Your application

Please apply via the official University of Copenhagen at the following link: Postdoc in imaging of synaptic function at Department of Neuroscience (ku.dk)

Providing your CV, a cover letter, copies of your PhD/master certificates, and two letters of recommendation.

Important! Only applications through the University of Copenahgen website will be taken into account.

Contact for further information: Prof. Jakob B. Sørensen; jakobbs@sund.ku.dk; phone: +45 5168 0499.