Job ID: 120199

Research Associate in Epigenomics UK Dementia Research Institute

Position: Post-doctoral Position

Deadline: 25 September 2024

City: London

Country: United Kingdom

Institution: Imperial College London

Department:

Description:

Applications are invited for a Research Associate in vascular-immune epigenomics to join the lab of Dr Alexi Nott in the UK DRI at Imperial.

About the role

Applications are invited for a Research Associate in vascular-immune epigenomics to join the lab of Dr Alexi Nott (https://nottgroup.com/index.html) in the UK DRI at Imperial.

Following a new award from the Alzheimer’s Association, you will lead one or more projects to characterise the epigenome of vascular-immune cell types in Alzheimer’s disease using patient-derived samples.  Based on the White City Campus under the guidance of Dr Alexi Nott, you will profile the epigenome and chromatin architecture of brain-derived vascular and immune cell types. You will contribute to the design and generation of large-scale ‘omics datasets with a primary focus on epigenomic analysis at single nuclei resolution to address major research questions relevant to Alzheimer’s disease and vascular pathology.

Today, over 1 million people in the UK are living with dementia and related neurodegenerative disorders, such as Alzheimer’s disease. The impact of these incurable and progressive conditions on individuals and their families is devastating. The cost to the economy and public services is large and growing as the UK population ages.

The UK DRI are a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.

Please contact Dr Alexi Nott for further discussion about the project and role.

 

What you would be doing

Using your experience in single nuclei (epi)genomics of the brain, you will:

  • Generate single-nuclei CUT&Tag data from patient-derived brain tissue and stem cell model systems.
  • Work collaboratively as part of a multidisciplinary research team.

 

What we are looking for

  • Experience of nuclei isolation, preferentially from brain and/or human tissue
  • Experience of fluorescence-activated nuclei sorting (FANS), and/or FACS
  • Experience of epigenomics and/or single-cell genomic technologies.
  • Research Associate: Hold a PhD (or equivalent) in neuroscience, biological sciences, or a closely related discipline, or equivalent research or industrial experience . *Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £41,694 – £44,888 per annum

 

What we can offer you

This role is part of the UK Dementia Research Institute (UK DRI) at Imperial College London, located in the Department of Brain Sciences.  Postdocs in the UK DRI at Imperial enjoy excellent career development opportunities with:

  • Access to a range of cutting-edge technologies.
  • An inclusive and collegial working environment with the opportunity to mentor, supervise and teach students.
  • Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’.
  • Support from the Postdoc and Fellows Development Centre (PFDC) and Imperial and UK DRI ECR Communities.
  • The opportunity to continue your career at a world-leading institution
  • Sector-leading salary and remuneration package (including 39 days off a year)

 

Further information

This is a full time and fixed -term role for two years based at the White City Campus.

 Applicants are encouraged to contact Dr Alexi Nott (a.nott@imperial.ac.uk) for an informal discussion about the project and the role.

 

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.

If you encounter any technical issues while applying online, please don’t hesitate to email us at support.jobs@imperial.ac.uk. We’re here to help.

About Imperial

Welcome to Imperial, a global top ten university where scientific imagination leads to world-changing impact.

Join us and be part of something bigger. From global health to climate change, AI to business leadership, here at Imperial we navigate some of the world’s toughest challenges. Whatever your role, your contribution will have a lasting impact.

As a member of our vibrant community of 22,000 students and 8,000 staff, you’ll collaborate with passionate minds across nine London campuses and a global network.

This is your chance to help shape the future. We hope you’ll join us at Imperial College London.

Our Culture

We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities. You can read more about our commitment on our webpages.

Our values are at the root of everything we do and everyone in our community is expected to demonstrate respect, collaboration, excellence, integrity, and innovation.