Job ID: 121955
Postdoc for work on human iPS cells and differentiation into neural lineages
Position: Post-doctoral Position
Deadline: 1 April 2025
Employment Start Date: 15 April 2025
Contract Length: 3 years
City: Paris
Country: France
Institution: Institut Pasteur
Department: Neuroscience
Description:
We are looking for a Postdoctoral fellow to take part in our human iPSC projects. These are described on our website
We are looking for a candidate with extensive skills in the culture, differentiation and analysis of iPSC cultures, for different neural lineages, and microglia. Further, we are transplanting pre-differentiated iPSC into immunodeficient animals, and experience with surgical techniques would be a bonus, but is not strictly required.
The ideal candidate will have carried out his PhD using human iPSC extensively, especially the differentiation into neurons and microglia. The appointment is for three years.
Application Procedure: To apply, please submit the following: An updated CV, a brief description of your scientific accomplishments and research interests. At this stage, reference letters are welcome but not mandatory. Candidates who pass the initial selection will be required to provide reference letters. Please send your application materials to umaskos@pasteur.fr
Relevant publications from the laboratory:
Görgülü I, Jagannath V, Pons S, Koniuszewski F, Groszer M, Maskos U, Huck S, Scholze P. The human-specific nicotinic receptor subunit CHRFAM7A reduces α7 receptor function in human induced pluripotent stem cells-derived and transgenic mouse neurons. Eur J Neurosci. 2024 Sep;60(5):4893-4906. doi: 10.1111/ejn.16474. PMID: 39073048
Raïs C, Gaspar Santos D, Sansone G, Blanchard S, Bourgeois JP, Jagla B, Saudemont B, Schlick L, Pons S, Maskos U. Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue. Front Cell Neurosci. 2023 Nov 23;17:1259712. doi: 10.3389/fncel.2023.1259712. eCollection 2023. PMID: 38077953
Llach Pou M, Thiberge C, Van der Zwan M, Devi Govindan A, Pons S, Maskos U, Cloëz-Tayarani I. Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero. Cells. 2023 Mar 31;12(7):1067. doi: 10.3390/cells12071067.PMID: 37048140
Vitrac A, Pons S, Balkota M, Lemière N, Raïs C, Bourgeois JP, Maskos U, Bourgeron T, Cloëz-Tayarani I. A chimeric mouse model to study human iPSC-derived neurons: the case of a truncating SHANK3 mutation. Sci Rep. 2020 Aug 7;10(1):13315. doi: 10.1038/s41598-020-70056-4.PMID: 32769989
D’Alessio R, Koukouli F, Blanchard S, Catteau J, Raïs C, Lemonnier T, Féraud O, Bennaceur-Griscelli A, Groszer M, Maskos U. Long-term development of human iPSC-derived pyramidal neurons quantified after transplantation into the neonatal mouse cortex. Dev Biol. 2020 May 1;461(1):86-95. doi: 10.1016/j.ydbio.2020.01.009. Epub 2020 Jan 23.PMID: 31982375