Job ID: 122881

Post-doctoral position in 3D organoids to study hereditary deafness

Position: Post-doctoral Position

Deadline: 1 June 2025

Employment Start Date: 1 July 2025

Contract Length: 1-3 years

City: Liege

Country: Belgium

Institution: University of Liege

Department: Developmental Neuroscience – GIGA Research

Description:

About the Lab & Research                                                                                                                                                                          The selected Candidate will join the Laboratory of Developmental Neuroscience, led by Prof. Brigitte Malgrange at GIGA (University of Liège), an internationally recognized group in the field of auditory neuroscience and neurodevelopment. The lab focuses on the molecular and cellular mechanisms regulating inner ear development, and regeneration.

Our research combines advanced molecular tools, transgenic models, stem cell-derived systems, and high-resolution imaging to investigate the signaling pathways controlling cell fate decisions and tissue organization in the nervous system. A particular emphasis is placed on understanding how these mechanisms are altered in developmental disorders and hearing loss, with potential applications in therapeutic strategies.

About the project

We are seeking a highly motivated and dedicated Postdoctoral Researcher to join our research team exploring the mechanisms of hereditary deafness using advanced 3D organoid models of the inner ear. The project will employ cutting-edge technologies including stem cell-derived otic organoids, biomimetic hydrogels, and microfluidic systems to model inner ear development and pathogenesis in vitro. This European project aims to develop a novel nanoparticle-based pharmacologic strategy for treating deafness. Among the different work packages, our lab is responsible of assessing the effect of the new formulation on 3D inner ear organoids.

Main Requirements & Skills

  • PhD in Developmental Biology, Stem Cell Biology, Neuroscience, or a related field.
  • Strong expertise in stem cell culture and differentiation.
  • Hands-on experience with confocal microscopy.
  • Team spirit, flexibility, independent and time effective working capacity, excellent organization, good communication skills and proficiency in English.

Position Details

  • Duration: The length of the appointment will be discussed during the interview process and will depend on the candidate’s experience and qualifications.
  • Compensation: Salary will be competitive and commensurate with experience.

Research Environment

GIGA is an interdisciplinary research center in biomedical sciences whose mission is advanced medical innovation. The institute encompasses more than 600 members with expertise in medical genomics, in silico medicine, neuroscience, cancer, infection and immunity, and cardiovascular sciences. GIGA is the only Belgian research center directly integrated within a university hospital, making it a significant player in translational research where links between researchers and doctors are at the heart of the research activity.

How to apply

Interested candidates (that had never worked in Belgium in the last year) are invited to submit directly to Prof. Brigitte Malgrange, bmalgrange@uliege.be  with:

  • A cover letter describing their research experience, skills, and motivation for applying.
  • A detailed curriculum vitae (CV).
  • Contact information for at least two references.