Job ID: 122972

BRAIN CIRCUITS

Position: Post-doctoral Position

Deadline: 1 August 2025

Employment Start Date: 1 October 2025

Contract Length: 4 years

City: Stockholm

Country: Sweden

Institution: Karolinska Institutet

Department: Neuroscience

Description:

The Meletis laboratory, in the Department of Neuroscience, has an open position for a postdoctoral fellow to investigate the function of circuits and neuron subtypes for motivated behavior and decision-making, including circuit dysfunction in mouse models of stress and mood disorders.

The research will focus on the functional investigation of neurons and circuits in shaping motivated behaviors through a number of advanced circuit approaches to target, record and manipulate genetically-defined neuron subtypes. The project will address the in vivo role of specific neuron subtypes in the basal ganglia, hypothalamus, and the lateral habenula.

The project will use and develop cell-type specific strategies in mice to image and manipulate neuron subtypes in vivo (e.g. with optogenetics) and sophisticated behavioral paradigms (freely moving and head-fixed) in a state-of-the-art infrastructure. The project will benefit from ongoing projects that have established the identity and connectivity of neuron subtypes in relevant circuits based on single cell RNA-seq and monosynaptic rabies tracing.

The research environment is highly collaborative, and offers many opportunities for career development.

We expect applicants to have a strong determination to reveal the function of neurons and circuits during behavior, with extensive experience and interest in behavior, imaging/optical methods and/or electrophysiology.