Job ID: 122973

BRAIN CIRCUITS – CONNECTIVITY AND FUNCTION

Position: Post-doctoral Position

Deadline: 1 August 2025

Employment Start Date: 1 October 2025

Contract Length: 4 years

City: Stockholm

Country: Sweden

Institution: Karolinska Institutet

Department: Neuroscience

Description:

The Meletis laboratory in the Department of Neuroscience at Karolinska Institutet has an open position for a postdoctoral fellow to investigate the principles underlying organization of brain circuits and the connectivity profile at single-neuron level, including the molecular and cellular mechanisms that can explain dysfunction in mouse models of stress and mood disorders.

The research will focus on how neuron subtypes are connected in local and long-range circuitries and the underlying molecular signals that define cell-type specific connectivity. We are looking for a postdoc to join our team,  with a strong experimental and statistical background with great interest in using new single-cell tools to better define the complexity of cell types and circuits in the nervous system.

The postdoctoral fellow will use opto-seq, long-read single-cell RNA-seq, spatial transcriptomics, together with viral-based approaches (e.g. barcoded rabies viruses) to define the molecular organization of brain circuits, the identity of neuron subtypes, and how neuronal diversity helps explain functional complexity.

The candidate must have extensive experience using advanced molecular and/or viral methods to define cell types, for example single-cell RNA sequencing or spatial transcriptomics, and a strong analytical and statistical background.

The candidate must have a strong publication track-record with at least one first-author publication. The candidate must have excellent communications skills and the ability to work productively in an interdisciplinary team.

The research environment is highly collaborative, and offers many opportunities for career development.