Lee Eiden

CountryUnited States

Society affiliation Mediterranean Neuroscience Society (MNS)

Position Principal Investigator/Group Leader

University/Organisation National Institute Of Mental Health Intramural Research Program

Domain Synaptic Integration, Excitability and Plasticity

Sub domains Pharmacology

Lab description

The overall goal of the Section on Molecular Neuroscience is to identify the cellular signaling components that allow neuropeptide GPCRs to control stress-responsive gene transcription. Pharmacological and genetic evidence indicates that neuropeptide slow transmitters represent “the language of the stressed nervous system” (Hokfelt et al., Lancet Neurology, 2003). Neuropeptide transmitters are important intervention points in injury, pain, drug abuse and stress. We have identified paraventricular nucleus, and central amygdala, as two loci at which the neuropeptide PACAP acts to mediate the endocrine and behavioral effects of restraint stress, and now seek to uncover intracellular the signaling pathways through which PACAP acts.

Lab URLhttps://www.nimh.nih.gov/research/research-conducted-at-nimh/principal-investigators/lee-eiden