Mia Lindskog

CountrySweden

Position Principal Investigator/Group Leader

University/Organisation Uppsala University

Domain Synaptic Integration, Excitability and Plasticity

Sub domains

Lab description

We are interested in understanding the synaptic tuning mechanisms that generate the robust—yet highly plastic—system that is the brain. We do field and patch-clamp recordings to directly assess synaptic activity an acute hippocampal slices from rats and mice combined with immunohistochemistry, western-blot analysis and animal behavior. Astrocytes are fundamental regulators of excitatory synaptic transmission, and the close synapse/astrocyte interaction makes this relationship intriguing to study. There is emerging results showing that many mental disorders are associated with defects in synaptic connectivity, and we think that this may be due to defective regulation by astrocytes, rather than a synaptic problem per se.

Lab URLhttps://www.uu.se/en/department/medical-cell-biology/research/research-groups/maria-lindskog